No FDA approved treatment for marijuana use disorder
 

Some evidence that N-acetyl cysteine and gabapentin might help especially for adolescent brains although the jury remains out on the topic 
 

Cochrane database unimpressed with pharmacotherapy results.  Nielsen S, Gowing L, Sabioni P, Le Foll B. Pharmacotherapies for cannabis dependence. Cochrane Database Syst Rev. 2019 Jan 28;1(1):CD008940. doi: 10.1002/14651858.CD008940.pub3. PMID: 30687936; PMCID: PMC6360924

• http://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008940.pub3/full
   

If going to offer medication, both have some promise but no guarantees.​

 

N-acetyl-cysteine 1200 mg BID (two tabs of 600mg) - over the counter

OR
 

Gabapentin 1200 mg PO BID

• NOTE!!  Most patients CANNOT TOLERATE 1200mg BID unless they have a co-occurring sedative or alcohol use disorder.    Avoid if any safety concerns.   

• Possible benefit if patient has co-occurring anxiety disorder

• Most patients will need to start at much lower dose e.g.  300mg BID-TID and then can be increased if tolerating at followup appointment